Dental Tribune Asia Pacific

New research provides faster cheaper method to treat periodontitis

By Dental Tribune International
May 17, 2019

SENDAI, Japan: Periodontitis affects many people and can have serious effects on oral health. In new research originating from Japan, scientists have developed a cell-based regenerative therapy approach. The proposed therapy design promises to address periodontitis without some of the shortcomings and limitations of regenerative therapies to date.

According to the researchers from Tohoku University in Sendai, the therapy will be faster and cheaper. “The use of cell-based therapies is a promising approach to treat human disease. This kind of treatment paradigm is important because commercially available stem cells that represent a cell-based therapy specifically developed to treat periodontal tissue regeneration will reduce time and cost while improving quality assurance,” said lead author Prof. Masahiro Saito, from the Department of Restorative Dentistry at Tohoku University Graduate School of Dentistry.

In a new approach to the treatment of periodontitis, the researchers transplanted stem cells from healthy mini pigs to those who had periodontal defects and, by doing so successfully, overcome the shortcomings that can be associated with autologous stem cell treatments. By using this mini pig periodontal defect model, they demonstrated that allogeneic adipose-derived mesenchymal progenitor stem cells (ADMPCs)—mesenchymal stem cells (MSCs) derived from fat tissue—are safe and effective for the treatment of periodontitis.

“Our study demonstrates that ADMPCs appear to be safe and not triggering an immune response in allogeneic settings, and as such it explores the potential use of allogeneic MSCs for tissue regeneration. The study is a powerful first step towards further development of stem cell-based therapy for the treatment of periodontal disease,” explained Saito.

The study, titled “Periodontal regeneration by allogeneic transplantation of adipose tissue derived multi-lineage progenitor stem cells in vivo”, was published on 29 January 2019 in Scientific Reports. The study was conducted in collaboration with researchers from Osaka University in Osaka and Fujita Health University in Toyoake.

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